Study Reveals TomoTherapy® Plays Key Role in Enabling Concurrent Chemo-Radiation Treatment

Clinical Trial from Brussels University Hospital in Belgium

MADISON, Wis – March 23, 2010 – TomoTherapy Incorporated (NASDAQ: TOMO), maker of advanced radiation therapy solutions for cancer care, today cited the first published results on the concurrent use of hypofractionated TomoTherapySM radiation treatments and chemotherapy for unresectable locally-advanced non-small cell lung cancer (NSCLC). The clinical trial was carried out by the Department of Radiation Oncology at the Universitaire Ziekenhuis (UZ) Brussel in Brussels, Belgium, and published in the journal Cancer (Volume 116, Issue 1, Pages 241-250, Jan 2010). Previous studies have shown an increase in the rate of tumor control via either escalating biologically effective radiation dose, or the addition of chemotherapy concurrent with the course of radiation. This trial tests the feasibility of dose escalation along with concurrent chemotherapy, taking advantage of the accuracy and dose conformity of helical TomoTherapy treatments in minimizing radiation damage to normal tissues.

The paper, “Toxicity Report of a Phase 1/2 Dose-Escalation Study in Patients With Inoperable, Locally Advanced Non-small Cell Lung Cancer With Helical TomoTherapy and Concurrent Chemotherapy”, concludes that a TomoTherapy schedule of 67.2 Gy in 30 fractions, concurrent with cisplatin/docetaxel, is feasible and has acceptable toxicity with a promising tumor response rate.

source: TomoTherapy